Defensive tackle Justin Smith, linebacker Patrick Willis, punter Andy Lee and placekicker David Akers all made the squad.
Smith was the key cog on the line for a Niners defense that was one of the league's premier units. He started all 16 games and made critical play after critical play for San Francisco.
Willis made 97 tackles despite missing three games. His 12 passes defensed and four forced fumbleswere both career-bests.
Lee is considered one of the NFL's best directional punters and he led the NFL in net average at 44.0 yards, including 28 punts inside the 20.
The 37-year-old Akers attempted a league-high 52 field goals, connecting on an NFL-record 44, including seven field goals (in nine attempts) from 50 yards or longer.
For more on the 49ers and their great season, visit Niners Nation.