The San Francisco 49ers have their division wrapped up, a guaranteed playoff spot, and a very happy fan base. That doesn't mean they can take a week off, especially travelling to Arizona to take on the rival Cardinals at University of Phoenix Stadium. The Niners still have to try and lock up the No. 2 seed in the NFC, and a win in Arizona would greatly help their chances.
According to Oddshark.com the 49ers open as a four point favorite over the Cardinals, while many of the other online betting sites list the line at 3.5. A very fitting line considering the confidence Arizona is playing with lately, the absence of the Niners defensive lynchpin in Patrick Willis, and the notion that weird things happen when these teams play each other; not to mention they simply don't like each other and almost always play a tightly contested match as well.
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