Gary Neal led the way with 17 points apiece, Tiago Splitter had 15, Tim Duncan added 13, Manu Ginobili netted 12, and Danny Green and DaJuan Blair chipped in 11 and 10, respectively to lift the Spurs, who have taken 14 straight from Golden State.
"Trying to win is part of it, trying to stay healthy is part of it," said San Antonio head coach Greg Popovich, who rested most of his starters in the second half. "That's got to be our main concern, not positioning."
San Antonio now sits tied for the top spot in the Western Conference after Oklahoma City lost to the Clippers on Monday.
Nate Robinson poured in a season-high 30 points, Klay Thompson followed with 29 and Dorrell Wright tallied 17 as the Warriors dropped their fifth straight.
"We understand where we are right now, we're shorthanded," Warriors head coach Mark Jackson said. "The energy and effort in the second half was acceptable. There's a way to go down and I can tolerate the second half. But the first half was disappointing."
The Warriors took their only lead early on at 5-2, but the Spurs registered the next 14 points and never looked back, taking a 39-24 advantage after one.
In the second, Ginobili tallied seven straight before Neal buried a three- pointer to extend the lead to 51-30 less than four minutes into the stanza.
Golden State got as close as 11 after two free throws from Robinson, but the lead quickly ballooned to 23 after a 14-2 swing found the Spurs on top 70-47 just before the break.
The lead was 16 early in the third when Neal, Green and Matt Bonner hit consecutive threes to spark a 13-0 run and press the advantage to 84-55.
The Spurs lead by as many as 32 in the frame and held a 96-72 edge after three quarters.
Golden State got no closer than 16 down the stretch as San Antonio coasted to the double-digit victory.
The Spurs were playing the first game of a back-to-back-to-back road stretch in the state of California, battling the Lakers on Tuesday and the Kings on Wednesday...Golden State will host the Lakers on Wednesday...San Antonio has won six in a row as the guest in this series.