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Week 5 NFL picks and predictions: Bills vs. 49ers

NFL experts have come to a consensus: the San Francisco 49ers are really good.

Debby Wong-US PRESSWIRE - Presswire

Entering their matchup this Sunday at Candlestick Park, the San Francisco 49ers and Buffalo Bills are going in opposite directions. The Niners shut out the New York Jets in dominating fashion on the road last week, while Buffalo's strong first half against the New England Patriots was erased with authority en route to a crushing defeat.

Can the Bills get a road win against one of the best teams in the league? Not according to most NFL experts.

Pete Prisco over at CBS Sports predicts a 23-10 win as the 49ers begin a three-week homestand. He sees Frank Gore having himself a great day against a struggling Buffalo defense.

The experts over at ESPN are unanimously picking San Francisco this week, who are looking to break a 5-5 tie in their all-time series against the Bills.

The folks at Walter Football are predicting a big 49ers win by the score of 30-6. They also note that 82 percent of all Vegas bets have been placed on San Francisco so far.