San Francisco 49ers WR Mario Manningham (shoulder) looks to have had a setback Friday after he sat out of practice and was slapped with a doubtful tag shortly after.
Manningham was able to get in two limited practice Wednesday and Thursday and most beat writers were expecting him to be ready to take on the New England Patriots Sunday. Now, it seems that the Niners will be shorthanded against a pass defense that has allowed an average of 199.5 yards over the past two weeks as CB Aqib Talib comes into his own.
Manningham also missed last week's game against the Miami Dolphins with the same shoulder injury. With Manningham out, WR Michael Crabtree (nine catches, 93 yards) was the only pass catcher able to get anything going; the six other players who caught at least one ball only combined for a total of 92 yards.
As for the rest of the injury report, LB Tavares Gooden (ribs), FB Bruce Miller (shoulder), LB Aldon Smith (shoulder), K David Akers (pelvis), LB NaVorro Bowman (shoulder), CB Chris Culliver (knee), RB Frank Gore (wrist), CB Tarell Brown (shoulder), CB Carlos Rodgers (knee), LB Patrick Willis (shoulder) and DT Will Tukuafu (wrist) were all listed as probable.