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49ers vs. Cardinals betting lines & odds

After three straight home games, the 49ers will go on the road to face Arizona in a game which San Francisco opened as a 4-point betting favorite.

Ed Mulholland-US PRESSWIRE

For the seventh straight week, the San Francisco 49ers are a betting favorite. San Francisco opened as a 4-point favorite for its game against the Arizona Cardinals on Monday.

The 49ers have been favored in every game since being a 6-point underdog in the season opener against Green Bay. Monday's game is the third time the 49ers have been favored as the road team this season. They are 2-1 against the spread on the road and 4-3 against the spread overall. While they opened as a 4-point favorite, they are currently a 7-point favorite in some casinos, according to Odds Shark.com.

San Francisco has dominated the head-to-head matchup against the Cardinals recently, winning seven of the last 10 games. The 49ers are 7-2-1 against the spread over that span. The total for the game opened at 37 points, but in the 14 games teams have played in this season, 10 have gone under. The total has also gone under in four of the last six head-to-head matchups.

While they started off 4-0, Arizona has lost three straight games and are 0-2-1 against the spread over that stretch. San Francisco has won five of it's last six games against Arizona.