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49ers vs. Giants betting lines and odds

The 49ers came in as favorites, and the line has only gotten larger as confidence grows in the team's ability to knock off the defending Super Bowl champion Giants.

Ed Mulholland-US PRESSWIRE - Presswire

The argument begins and ends with the San Francisco 49ers against the New York Giants as the NFL game of the week. The defending champions will travel to the West Coast to face the team looking to replace them as the NFC's representative in the Super Bowl this season.

The opening line reflects the closeness of the matchup, as the Niners were just three-point favorites. But the line has moved to at least six points on more than one website, which shows more faith in the Niners pulling out a victory at home.

The Giants come in with the more explosive offense. The Niners come in with the dominant defense. Though those two sides of the ball are the highlights, it may come down to the Niners offense against the Giants defense, especially after the Niners put up 621 yards on the Buffalo Bills in a 45-3 win Sunday.

The Giants are 3-2 and the Niners are 4-1, and both teams will look to gain confidence with a signature win over a fellow NFC contender.