49ers vs. Seahawks, NFL Week 16
You wouldn't be able to design a worse scenario for the Niners than the one that happened Sunday night in Seattle. Not only were they dominated 42-13, being outplayed in every phase of the game, they also lost Mario Manningham for the season.
The answer is yes. In their first matchup, San Francisco's offensive line dominated Seattle's run defense on their way to 175 yards on the ground. Frank Gore led the way to a 13-7 victory at Candlestick. Week 16 should see more of the same.