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2012 U.S. Open Scores: Roger Federer, Andy Roddick Eliminated Wednesday

Wednesday was a busy day at the 2012 U.S. Open, with eight fourth-round or quarterfinal matches and two notable names going home.

Men's No. 1 Roger Federer was the biggest name eliminated on Wednesday, as he lost to No. 6 Tomas Berdych. Federer lost the first set on a tiebreaker and was never able to recover, with Berdych winning 7-6, 6-4, 3-6, 6-3. Andy Roddick's career came to a close when he lost to No. 7 Juan Martin del Potro. Earlier this week Roddick announced he plans to retire following the U.S. Open.

Three men's top-10 seeds did advance Wednesday with No. 2 Novak Djokovic, No. 3 Andy Murray and No. 8 Janko Tipsarevic all moving on. Murray's win against No. 12 Marin Cilic moves him onto the semifinals, while Djokovic and Tipsarevic advanced to the quarterfinals.

While the top seed on the men's side fell, the favorites on the women's side all advanced on Wednesday. No. 3 Maria Sharapova, No. 4 Serena Williams and No. 10 Sara Errani all moved onto the semifinals. Williams won in straight sets against No. 12 Ana Ivanovic and has yet to drop a set in her first five matches.

A complete schedule for Wednesday can be found at the official U.S. Open site, with live men's and women's scoreboards available from Sports Illustrated.

For more coverage of the 2012 U.S. Open, check out SB Nation's tennis hub.