After Stanford began its season with a slim 20-17 victory over San Jose State, the Cardinal open as two-touchdown favorites over Duke on Saturday.
The Cardinal rushed for two first-quarter touchdowns and got out to an early 14-0 lead over San Jose State before yielding to the Spartans. San Jose State tied the game at 17 before Jordan Williamson's 20-yard field goal gave Stanford its lead for good with 13:15 left to play.
Stanford converted just 2-of-13 on third down in the opener.
The Blue Devils won their opener, a 46-26 rout over Florida International. Duke took control of that game during a 30-point second quarter that included two touchdown passes, two touchdown runs, a field goal and a blocked field goal returned for a touchdown.
Still, Stanford opens Saturday's game as a 14-point favorite in the second game of quarterback Josh Nunes' starting career as Andrew Luck's replacement.
The Cardinal play Duke at 7:30 p.m. PT on Saturday.