Despite injuries to Brandon Jacobs and Ted Ginn Jr., rookies LaMichael James and A.J. Jenkins were not able to crack the 46-man active roster for Sunday's game against the Detroit Lions.
Head coach Jim Harbaugh instead elected to go the more experienced route with WR Kyle Williams filling in on punts and RB Kendall Hunter acting as Frank Gore's relief.
Along with the rookies plus Jacobs and Ginn Jr., G Joe Looney, TE Garrett Celek and NT Ian Williams are the other players that won't be suiting up for the 49ers.
On the Lions' end, Detroit will be without some major pieces in their secondary as cornerbacks Bill Bently and Chris Houston join FS Louis Delmas on the bench for this one. WR Ryan Broyles will also be making his NFL debut after being a healthy scratch Week 1 against the St. Louis Rams.
The rest of Detroit's inactives are as follows: LB Travis Lewis, OT Jason Fox, OT Corey Hilliard and QB Kellen Moore.
Stick with this StoryStream for updates, scores and more from the Lions vs. 49ers game. For more insight and analysis, check out 49ers blog Niners Nation. For the perspective from Detroit, check out Lions blog Pride of Detroit.