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Stanford vs. Oregon betting line: Ducks 21.5-point favorites over Cardinal

In a must-win for Stanford, the Cardinal open as three touchdown underdogs against undefeated Oregon.

Ezra Shaw

With a trip to the Rose Bowl on the line, Stanford needs to be in upset mode on Saturday against an Oregon team that is favored by 21.5 points. Coming off a narrow 27-23 win over Oregon State, the Cardinal have secured the number two spot in the Pac-12 North division. But a win against Oregon would tie them for first and prime them for a run to the Rose Bowl.

Oregon has been rolling teams, including a 59-17 cakewalk against Cal on Saturday. The Ducks are averaging 54.8 points per game, easily the best in the nation. But Stanford's strength is their defense, which is 12th in the country in scoring, holding opponents to just over 17 points per game.

Stanford has dropped their last two games to Oregon after defeating them in 2009.

Following this game, each team still has a tough task to close out the season. Oregon plays in the Civil War against No. 16 Oregon State, while Stanford must face a UCLA Bruins team that is ranked 17th in the country.