The starting running back remains out with a high ankle sprain, and he was joined by defensive tackle Richard Seymour and fellow running back Mike Goodson. McFadden was limited in practices in the middle of last week but then was absent on Thursday before missing the Raiders' game against the New Orleans Saints on Sunday.
McFadden's injury was initially reported to cost the running back two to four weeks.
Seymour continues to remain out with a knee injury, and Goodson is sitting with his own ankle issue.
Denarius Moore was limited in practice with a hamstring injury as was fellow receiver Darrius Heyward-Bey. Safety Tyvon Branch was limited with a neck injury, and tight end Brandon Myers took it easy thanks to a shoulder problem.
Marcel Reece, who has taken the majority of McFadden's reps at running back, was a full participation on Wednesday despite being listed with a hamstring and quadriceps injury.
The Raiders head to Cincinnati to face the streaking Bengals on Sunday.