The San Francisco 49ers open as 10-point favorites against the Miami Dolphins.
Jim Harbaugh's team holds most of the advantages going into the weekend. They'll have home field at Candlestick Park, where the 49ers have been 14-3-1 straight up and 12-4-2 against the spread in their past 18 games. On the road, the Dolphins are 4-11 straight up in the past 15 games.
San Francisco also holds the statistical advantages. It averages 24 points per game, five more than Miami, and holds opponents to 14.3 points, more than six points less than the Dolphins allow.
The game's total sits at 39 points. Of Miami's last eight games, the total has gone under in seven outings, and with their defensive emphasis to go along with the 49ers struggling to score last week against the St. Louis Rams, that could happen once again. The total has gone under in four of the teams' last six meetings.