The 49ers made some roster moves to fill the holes after placing Kendall Hunter and Kyle Williams on the injury reserve.
The Niners also activated undrafted rookie running back Jewel Hampton off the non-football injury list earlier in the week to fill the 53-man roster holes.
Wilhoite saw some snaps at fullback during the offseason and exhibition games but was cut in the final round of the 49ers training camp. The team promptly signed him to the practice squad.
Wilhoite graduated in 2011 from Washburn College, a Division II school in Kansas. He started 35 games at Washburn and was a three-time captain and in 2007 became the first Washburn College player to return an interception for a touchdown in the post-season.
Williams season ended with a ACL tear in his left knee and Kendall went down with an Achilles tendon injury. They were both hurt last week on the second-to-last play of the third quarter the 49ers' 31-21 win over the New Orleans Saints.