49ers vs. Bills postgame: Third down success sparks record-breaking day

A look at the 49ers success on third down and some of the ridiculous stats from their record-breaking offensive performance against the Buffalo Bills.

Alex Smith hurts finger on final pass, but it doesn't appear to be serious

Quarterback Alex Smith sprained his middle finger on his throwing hand against the Buffalo Bills on Sunday.

49ers players react to record-setting offensive performance against Bills

The 49ers offense did things that no San Francisco team or NFL team had done before on Sunday, and the players are pretty happy about it.

49ers vs. Bills injury report: X-ray negative on Alex Smith's finger

The X-ray on Alex Smith's finger turned out to be negative.

49ers vs. Bills postgame: San Francisco earns statement win

Niners Nation reacts to a second consecutive blowout victory by the San Francisco 49ers.

NFC West standings, Week 6: 49ers, Cardinals tied atop division

An updated look at the NFC West standings after Week 5 of the 2012 NFL Season.

49ers vs. Bills postgame: Some notes from San Francisco's win

Some notes from the San Francisco 49ers' win over the Buffalo Bills on Sunday.

49ers vs. Bills final score: San Francisco dominates in 45-3 win

The San Francisco 49ers racked up 621 offensive yards on their way to a 45-3 win over the Bills.

49ers vs. Bills score update: San Francisco leads Buffalo 24-3

The San Francisco 49ers continued to build on their halftime lead and take a 24-3 advantage into the fourth quarter.

The 49ers got another quick score early in the second half thanks to a one yard touchdown run by Frank Gore. Gore capped off a five play, 66 yard drive that took a little under three minutes.

Quarterback Alex Smith continues to take apart the Buffalo defense. He is 17/21 for 293 yards and two touchdowns heading into the fourth. His QB rating is a near-perfect 150.5 so far.

Gore, meanwhile has 89 yards and a score on just 12 carries, good for an average of 7.4 yards per attempt.

Two San Francisco receivers have already eclipsed 100 yards on the day--Michael Crabtree has six receptions for 113 yards and a score, while Vernon Davis has 106 yards including a 53 yard grab.

San Francisco cornerback Chris Culliver picked off quarterback Ryan Fitzpatrick midway through the quarter. It was Buffalo's second turnover of the day.

49ers vs. Bills score update: San Francisco leads 17-3 at halftime

The San Francisco 49ers lead the Buffalo Bills 17-3 at halftime.

The Bills tied the game up early in the second quarter thanks to a 31-yard field goal by kicker Rian Lindell. Buffalo managed to shake off a sluggish first quarter start to get on the scoreboard, marching down the field on a 12-play, 75-yard drive.

But the 49ers responded less than a minute later, after Alex Smith connected on back-to-back passes to different wide receivers. Smith first hit Michael Crabtree on a 36-yard strike, and that set up a 43-yard touchdown pass to wide receiver/kick returner Kyle Williams.

San Francisco appeared to end the half on a sour note when backup quarterback Colin Kaepernick fumbled in the red zone. But Buffalo coughed the ball up just a few plays later, and San Francisco converted on a 28-yard touchdown to Crabtree.

San Francisco outgained Buffalo 320 to 123 in total yards. Alex Smith has been near perfect so far, completing 12 out of 15 attempts for 237 yards and two touchdowns. He also has a 24-yard run.

49ers vs. Bills score update: San Francisco leads 3-0

The San Francisco 49ers lead the Buffalo Bills 3-0 after the first quarter of play at Candlestick Park.

The 49ers have kept Buffalo's offense from establishing any sort of momentum. The Bills had just three first downs and 36 total yards. Quarterback Ryan Fitzgerald finished the quarter 4-6 for 30 yards, while running backs Fred Jackson and C.J. Spiller combined for six yards on five carries.

San Francisco, meanwhile, put points on the board following a six-play, 79-yard drive that ended with a 19-yard field goal by kicker David Akers. San Francisco was able to move the ball down the field thanks to tight end Vernon Davis, who pulled in a 53 yard reception.

Quarterback Alex Smith is an efficient 5-6 for 101 passing yards. Running back Frank Gore has accumulated 31 yards on five carries.

Neither team has committed a turnover thus far in the low-scoring affair.

Bills vs. 49ers inactives, NFL Week 5: Brandon Jacobs, LaMichael James continue to sit for San Francisco

The San Francisco 49ers declared inactive running backs Brandon Jacobs and LaMichael James once again. The Buffalo Bills will be without Cordy Glenn and Kirk Morrison.

NFL TV coverage map: Week 5 features 49ers, Ravens vs. Chiefs

A look at the TV coverage maps for Week 5 in the Bay Area.

Bills vs. 49ers 2012: Game time, TV schedule, odds and more

The San Francisco 49ers will try to move to 4-1 as they welcome in the Buffalo Bills to Candlestick Park in a Week 5 matchup.

49ers vs. Bills injury report: Carlos Rogers questionable for Week 5

The 49ers and Bills have released their injury reports for their Week 5 matchup in San Francisco.

49ers vs. Bills: Turnovers and lack of defensive consistency will doom Bills

Bills weaknesses play perfectly in to 49ers' hands. Turnovers, soft defense, injuries will doom the Bills at Candlestick on Sunday.

Brandon Jacobs listed as questionable heading into Sunday

San Francisco 49ers running back Brandon Jacobs turned in a full week of practice, but is officially listed as questionable on the team's official injury report.

Jacobs suffered a right knee injury during the 49ers' preseason game in Houston on Aug. 18 when he took a helmet directly to his left knee. At the time, the injury looked to be serious, but he suffered no significant structural damage and is in line to see his first regular season NFL action of 2012 in Week 5 against the Bills at home.

The 49ers have struggled in short yardage situations and on third down, converting just 14-of-42 third down opportunities through four games.

Jacobs figures to give starter Frank Gore some relief in that role and keep the primary running back's legs fresh for the rigors of a full season. The 6'4, 264 lb. Jacobs was acquired as a free agent after spending the beginning of his career as a member of the New York Giants, where he won two Super Bowl rings.

49ers vs. Bills: Rookies not bothered by inactive list

San Francisco 49ers rookies like LaMichael James, A.J. Jenkins and Joe Looney have had trouble seeing the field on a stacked Niners roster.

49ers' Greg Roman avoids talk of potential trick play

Offensive coordinator plays coy when asked about backup quarterback Colin Kaepernick lining up at wide receiver.

49ers vs. Bills: Can San Francisco exploit thin Buffalo offense?

The San Francisco 49ers may be 3-1, but they have a lot of work to do to solidify themselves as an elite team once again. It starts on Sunday in San Francisco by exploiting the Buffalo Bills' thinning offense.

49ers vs. Bills: Containing C.J. Spiller

The 49ers defense is always stout against the run, but mostly with powerful runners who don't threaten the edge much. They'll need to contain C.J. Spiller not only in the run game, but on swing-passes and screens, too.

49ers vs. Bills: Isaac Sopoaga, NaVorro Bowman, Carlos Rogers limited, everyone practicing

The San Francisco 49ers had all their players practice on Thursday before Sunday's game against the Buffalo Bills, with Isaac Sopoaga, NaVorro Bowman and Carlos Rogers all limited.

Patrick Willis named NFC Defensive Player of the Week

San Francisco 49ers linebacker Patrick Willis was named Defensive Player of the Week after his outstanding performance against the Jets last week in New York.

Willie Mays visits 49ers at Wednesday practice

San Francisco Giants legend Willie Mays showed some love to the San Francisco 49ers on Wednesday by paying a visit to their practice at team headquarters.

49ers vs. Bills: Andy Lee excelling despite broken hand

San Francisco punter Andy Lee has continued to kick well despite a broken hand.

49ers sit/start: Gore, Davis could have big days for fantasy teams

The Niners host the Bills on Sunday, and some Niners are great plays for your fantasy teams.

Week 5 NFL picks and predictions: Bills vs. 49ers

NFL experts have come to a consensus: the San Francisco 49ers are really good.

49ers vs. Bills: Isaac Sopoaga back at practice on Wednesday

San Francisco 49ers defensive tackle Isaac Sopoaga returned to the practice field on Wednesday.

49ers' Carlos Rogers says Jets looked like they didn't want to be there

Carlos Rogers describes how the Jets players just wanted to go home during last Sunday's beat down in New York.

49ers vs. Bills: Colin Kaepernick forcing Buffalo to account for him

The Bills are trying to prepare for the dangerous Colin Kaepernick this week.

49ers vs. Bills: San Francisco RB Brandon Jacobs 'ready to play'

Free agent acquisition Brandon Jacobs has yet to play for the 49ers, but the running believes he is ready to go.

49ers vs. Bills key matchup: Niner offensive line faces off against Bills pass rush

Coming off the dismantling of the Jets last week, the Niners offensive line will have their hands full with a formidable Buffalo defensive front four.

Frank Gore not bothered by sharing the football

Frank Gore's attempts per game are slightly down in 2012, but he and the 49ers backfield are performing well.

49ers vs. Bills betting lines & odds

The Niners and Bills enter Sunday's game coming off very different outcomes in their previous contests

49ers vs. Bills preview: San Francisco should be wary of overlooking another opponent

The San Francisco 49ers may have overlooked the Minnesota Vikings in Week 3, but after a win over the New York Jets, they won't be overlooking the Buffalo Bills in Week 5.