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49ers vs. Bills: San Francisco destroys Buffalo

Alex Smith threw for 303 yards and three touchdowns, and the defense was dominant again as the San Francisco 49ers beat the Buffalo Bills 45-3 on Sunday afternoon.

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49ers success on third down sparks success

A look at the 49ers success on third down and some of the ridiculous stats from their record-breaking offensive performance against the Buffalo Bills.


49ers excited about offensive explosion

The 49ers offense did things that no San Francisco team or NFL team had done before on Sunday, and the players are pretty happy about it.


X-ray negative on Alex Smith's finger

The X-ray on Alex Smith's finger turned out to be negative.


San Fransisco claims 'statement' win

Niners Nation reacts to a second consecutive blowout victory by the San Francisco 49ers.


49ers vs. Bills postgame notes

Some notes from the San Francisco 49ers' win over the Buffalo Bills on Sunday.


49ers cruise to 45-3 win over Bills

The San Francisco 49ers racked up 621 offensive yards on their way to a 45-3 win over the Bills.


49ers lead Bills 24-3 after three quarters

The San Francisco 49ers continued to build on their halftime lead and take a 24-3 advantage into the fourth quarter.

The 49ers got another quick score early in the second half thanks to a one yard touchdown run by Frank Gore. Gore capped off a five play, 66 yard drive that took a little under three minutes.

Quarterback Alex Smith continues to take apart the Buffalo defense. He is 17/21 for 293 yards and two touchdowns heading into the fourth. His QB rating is a near-perfect 150.5 so far.

Gore, meanwhile has 89 yards and a score on just 12 carries, good for an average of 7.4 yards per attempt.

Two San Francisco receivers have already eclipsed 100 yards on the day--Michael Crabtree has six receptions for 113 yards and a score, while Vernon Davis has 106 yards including a 53 yard grab.

San Francisco cornerback Chris Culliver picked off quarterback Ryan Fitzpatrick midway through the quarter. It was Buffalo's second turnover of the day.


49ers lead Bills 17-3 at halftime

The San Francisco 49ers lead the Buffalo Bills 17-3 at halftime.

The Bills tied the game up early in the second quarter thanks to a 31-yard field goal by kicker Rian Lindell. Buffalo managed to shake off a sluggish first quarter start to get on the scoreboard, marching down the field on a 12-play, 75-yard drive.

But the 49ers responded less than a minute later, after Alex Smith connected on back-to-back passes to different wide receivers. Smith first hit Michael Crabtree on a 36-yard strike, and that set up a 43-yard touchdown pass to wide receiver/kick returner Kyle Williams.

San Francisco appeared to end the half on a sour note when backup quarterback Colin Kaepernick fumbled in the red zone. But Buffalo coughed the ball up just a few plays later, and San Francisco converted on a 28-yard touchdown to Crabtree.

San Francisco outgained Buffalo 320 to 123 in total yards. Alex Smith has been near perfect so far, completing 12 out of 15 attempts for 237 yards and two touchdowns. He also has a 24-yard run.


49ers lead Bills 3-0 after first quarter

The San Francisco 49ers lead the Buffalo Bills 3-0 after the first quarter of play at Candlestick Park.

The 49ers have kept Buffalo's offense from establishing any sort of momentum. The Bills had just three first downs and 36 total yards. Quarterback Ryan Fitzgerald finished the quarter 4-6 for 30 yards, while running backs Fred Jackson and C.J. Spiller combined for six yards on five carries.

San Francisco, meanwhile, put points on the board following a six-play, 79-yard drive that ended with a 19-yard field goal by kicker David Akers. San Francisco was able to move the ball down the field thanks to tight end Vernon Davis, who pulled in a 53 yard reception.

Quarterback Alex Smith is an efficient 5-6 for 101 passing yards. Running back Frank Gore has accumulated 31 yards on five carries.

Neither team has committed a turnover thus far in the low-scoring affair.


Brandon Jacobs inactive for 49ers

The San Francisco 49ers declared inactive running backs Brandon Jacobs and LaMichael James once again. The Buffalo Bills will be without Cordy Glenn and Kirk Morrison.


NFL Week 5 TV schedule across the Bay Area

A look at the TV coverage maps for Week 5 in the Bay Area.


49ers look to win 2nd straight against Buffalo

The San Francisco 49ers will try to move to 4-1 as they welcome in the Buffalo Bills to Candlestick Park in a Week 5 matchup.


Turnovers and defensive inconsistencies doom Bills

Bills weaknesses play perfectly in to 49ers' hands. Turnovers, soft defense, injuries will doom the Bills at Candlestick on Sunday.


49ers rookies aren't bothered by the lack of PT

San Francisco 49ers rookies like LaMichael James, A.J. Jenkins and Joe Looney have had trouble seeing the field on a stacked Niners roster.


Roman remains coy about Kaepernick's trick play

Offensive coordinator plays coy when asked about backup quarterback Colin Kaepernick lining up at wide receiver.


49ers' running game key to victory vs. Bills

The San Francisco 49ers may be 3-1, but they have a lot of work to do to solidify themselves as an elite team once again. It starts on Sunday in San Francisco by exploiting the Buffalo Bills' thinning offense.


49ers vs. Bills: No cup can Spiller over

The 49ers defense is always stout against the run, but mostly with powerful runners who don't threaten the edge much. They'll need to contain C.J. Spiller not only in the run game, but on swing-passes and screens, too.


Patrick Willis wins player of the week award

San Francisco 49ers linebacker Patrick Willis was named Defensive Player of the Week after his outstanding performance against the Jets last week in New York.


Willie Mays stops by 49ers practice

San Francisco Giants legend Willie Mays showed some love to the San Francisco 49ers on Wednesday by paying a visit to their practice at team headquarters.


Not even a broken hand can stop Andy Lee

San Francisco punter Andy Lee has continued to kick well despite a broken hand.


Niners best and worst fantasy options vs. Bills

The Niners host the Bills on Sunday, and some Niners are great plays for your fantasy teams.


NFL experts predict a 49ers win over the Bills

NFL experts have come to a consensus: the San Francisco 49ers are really good.


49ers NT Sopoaga returns to practice Wednesday

San Francisco 49ers defensive tackle Isaac Sopoaga returned to the practice field on Wednesday.


Carlos Rogers, 49ers defense gave Jets no quarter

Carlos Rogers describes how the Jets players just wanted to go home during last Sunday's beat down in New York.


Bills prepare for Colin Kaepernick

The Bills are trying to prepare for the dangerous Colin Kaepernick this week.


Brandon Jacobs is 'ready to play'

Free agent acquisition Brandon Jacobs has yet to play for the 49ers, but the running believes he is ready to go.


Niners face challenge in Bills defensive line

Coming off the dismantling of the Jets last week, the Niners offensive line will have their hands full with a formidable Buffalo defensive front four.


Frank Gore not bothered by sharing the football

Frank Gore's attempts per game are slightly down in 2012, but he and the 49ers backfield are performing well.


The 49ers are favorites over the Bills on Sunday

The Niners and Bills enter Sunday's game coming off very different outcomes in their previous contests

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