Following a Colin Kaepernick interception on the 49ers first drive, the San Francisco defense forced a Stevan Ridley fumble. The 49ers capitalized with Frank Gore picking up a fumbled snap and running for a touchdown to move the lead to 24-3.
The 49ers forced a second turnover on the Patriots' next drive by picking off Tom Brady on a screen pass intended for Aaron Hernandez. Kaepernick then found Michael Crabtree on a 27-yard touchdown connection to widen the gap.
New England finally put together a strong drive on the ensuing possession with Danny Woodhead capping it off with a 6-yard touchdown run. After forcing a 49ers punt, the Patriots once again moved the ball into San Francisco territory and reached the red zone before the third quarter concluded.