The San Francisco 49ers don't have any big holes at any big position, particularly based on their draft placement. With a low pick in the first round of the 2012 NFL Draft, they won't be able to get any top marquee talent. However, San Francisco proved that they could find good players regardless, so draft positioning might not matter so much.
The 49ers look to continue replenishing what is proving to be a strong defense, as in one particular mock draft, they draft two defensive players with their first two picks, with Zach Brown of the North Carolina Tar Heels going in the first round and Billy Wynn of the Boise St. Broncos picked in the second. It'd be an unorthdox move considering how good San Francisco looks defensively, but some of the playmakers for the Niners are on the older side, it might not be the worse move to make.
Interestingly, San Francisco waits until the third round to get a wide receiver, arguably a position of need. T.Y. Hilton of Florida International is elected. Then safety George Iloka of Boise State is picked at safety in the fourth round to help shore up a position where the Niners haven't been too strong defensively.
To discuss the 49ers and the NFL Draft, head to Niners Nation.